Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration.

Yuan-Yuan ChengZachery GregorichRay P PrajnamitraDavid J LundyTing-Yun MaYu-Hsuan HuangYi-Chan LeeShu-Chian RuaJen-Hao LinPo-Ju LinChiung Wen KuoPeilin ChenYu-Ting YanRong Tian Timothy J Kamp Patrick Ching-Ho Hsieh

Published in: Circulation (2022)

Our data demonstrate the importance of HMGCS2-induced ketogenesis as a means to regulate metabolic response to CM injury, thus allowing cell dedifferentiation and proliferation as a regenerative response.

Keyphrases

stem cells
cell therapy
high glucose
single cell
mesenchymal stem cells
signaling pathway
diabetic rats
electronic health record
big data
drug induced
heart failure
young adults
machine learning
tissue engineering
artificial intelligence