CDC42 as an epigenetic regulator of ID4 in triple-negative breast tumors.

Daniela NasifSebastian RealMaría RoquéMaría Teresita Branham

Published in: Breast cancer (Tokyo, Japan) (2022)

We show that CDC42 silences ID4 through methylation in TN breast cancer. Given that ID4 acts as an oncogene in these tumors, we think that finding an epigenetic regulator of ID4 contributes to the research and clinical management of TN breast tumors.

Keyphrases

dna methylation
gene expression
transcription factor
cell cycle
cell proliferation