A New Saquinavir Mesylate-Sodium Decyl Sulfate Salt Discovered by Serendipity during an Anomalous Dissolution Test.
Cinira FandaruffThiago CaonAndrea Mariela Araya-SibajaGabriela Schneider RauberMarcos Antônio Segatto SilvaCláudia Maria Oliveira SimõesCarlos Eduardo Maduro de CamposAdailton João BortoluzziJackson Antônio Lamounier Camargos ResendeSilvia Lucia CuffiniPublished in: Pharmaceutical research (2022)
Some of the strategies to enhance the dissolution rate of poorly aqueous soluble APIs include the use of surfactants such as SDS in the dissolution medium, as well as in the formulated products. However, there have been constant reports of a dissolution rate slowdown by some surfactants. The interaction mechanisms between the APIs and the dissolution medium containing surfactants need to be carefully investigated in current pharmaceutical formulations. Graphical Abstract.