PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells.

Tianjiao LiQiwen ChenYi ZhengPengfei ZhangXiaoxu ChenJunna LuYinghua LvShiguo SunWenxian Zeng

Published in: Stem cell research & therapy (2019)

This study thus provides a promising nanovector for siRNA delivery in SSCs, facilitating the future clinical application of SSC auto-transplantation with genetically modified cells with a hope to cure male infertility that is caused by genetic disorders.

Keyphrases

stem cells
induced apoptosis
cancer therapy
cell cycle arrest
current status
gene expression
type diabetes
metabolic syndrome
insulin resistance