Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx.

Yu-Syuan WeiYu-Liang ChenWei-Yun LiYa-Yi YangSung-Jan Lin Ching-Ho Wu Jiue-In Yang Tse-En Wang Jia-Shing Yu Pei-Shiue Jason Tsai

Published in: International journal of nanomedicine (2023)

Taken together, the nanoparticulated antioxidant counteracts cisplatin-induced male fertility defects and benefits patients undertaking cisplatin-based chemotherapy. These data may allow the reintroduction of cisplatin for systemic applications in patients at clinics with reduced testicular toxicity.

Keyphrases

dna repair
dna damage
oxidative stress
primary care
dna damage response
anti inflammatory
squamous cell carcinoma
patient reported outcomes
artificial intelligence
data analysis
walled carbon nanotubes