Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes.
Matias MosqueiraGüçlü AykutRainer H A FinkPublished in: BMC anesthesiology (2020)
At cellular level, mepivacaine blocks Na+ channels, enhancing the reverse mode activity of NCX, leading to a significant reduction of Ca2+ transients. These results suggest a new mechanism for the mepivacaine-reduction contractility effect.