Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention.

Tao MaChen LiuQuanlai ZhaoYu ZhangLiang Xiao

Published in: Molecular medicine (Cambridge, Mass.) (2024)

GDF5-loaded microspheres combined with DNPM/chitosan composite hydrogels can effectively promote the differentiation of NPSCs into nucleus pulposus-like cells and effectively preventIDD.

Keyphrases

drug delivery
wound healing
stem cells
cancer therapy
drug release
hyaluronic acid
tissue engineering
extracellular matrix
molecularly imprinted
cell therapy
mass spectrometry
bone marrow
mesenchymal stem cells
simultaneous determination
liquid chromatography