Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis.
Zoe QuandtStephanie KimJavier Villanueva-MeyerCatherine CoupeArabella YoungJee Hye KangRebecca GraingerGabriela SchmajukStephanie RushElad ZivAna Luisa PerdigotoKevan HeroldMelissa G LechnerMaureen A SuJ Blake TyrrellJeffrey BluestoneMark AndersonUmesh MasharaniPublished in: Journal of the Endocrine Society (2023)
The association of CPI-hypophysitis with HLA DQ0602 suggests a genetic risk for its development. The clinical phenotype of hypophysitis appears heterogenous, with differences in timing of onset, changes in thyroid function tests, MRI changes, and possibly sex related to CPI type. These factors may play an important role in our mechanistic understanding of CPI-hypophysitis.