ATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production.

Xiaojuan DaiXuan FangYuan XiaManyun LiXiaomei LiYiping WangJin-Hui TaoXiangpei Li

Published in: Journal of inflammation research (2022)

Activation of P2X7R by ATP aggravated the development of acute gouty arthritis through P2X7R/NLRP3 pathway, promoted the secretion of related inflammatory cytokines, which affected radio of Tregs/Th17 cells. The whole pathogenesis process appeared a pattern from acute attack to remission in time-dependent trend.

Keyphrases

liver failure
nlrp inflammasome
respiratory failure
drug induced
rheumatoid arthritis
aortic dissection
induced apoptosis
oxidative stress
hepatitis b virus
intensive care unit
cell cycle arrest
extracorporeal membrane oxygenation
cell proliferation
endoplasmic reticulum stress
cell death