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Sleeping Beauty transposon integrates into non-TA dinucleotides.

Yabin GuoYin ZhangKaishun Hu
Published in: Mobile DNA (2018)
The TA-preference of SB transposon is not as strict as what people had thought. And the SB integrations at non-TA sites might be guided by the interaction between the transposon DNA binding domain of SB transposase and the target DNA.
Keyphrases
  • dna binding
  • transcription factor
  • circulating tumor
  • single molecule
  • nucleic acid