Genetic Landscape of the ACE2 Coronavirus Receptor.
Zhijian YangErin Macdonald-DunlopJiantao ChenRanran ZhaiTing LiAnne RichmondLucija KlarićNicola PirastuZheng NingChenqing ZhengYipeng WangTingting HuangYazhou HeHuiming GuoAlbert K YingStefan GustafssonBram PrinsAnna RamischEmmanouil T DermitzakisGrace PngNiclas ErikssonJeffrey HaesslerXiaowei HuDaniela ZanettiThibaud BoutinShih-Jen HwangEleanor WheelerMaik PietznerLaura M RaffieldAnette KalnapenkisJames E PetersAna ViñuelaArthur GillySölve ElmståhlGeorge DedoussisJohn R PetrieOzren PolašekLasse FolkersenYan ChenChen YaoUrmo VõsaErola Pairo-CastineiraSara ClohiseyAndrew D BretherickKonrad Rawliknull nullnull nullTõnu EskoStefan EnrothÅsa JohanssonUlf GyllenstenClaudia LangenbergDaniel LevyCaroline HaywardThemistocles L AssimesCharles KooperbergAni W ManichaikulAgneta SiegbahnLars WallentinLars LindEleftheria ZegginiJochen M SchwenkAdam S ButterworthKarl MichaëlssonYudi PawitanPeter K JoshiJ Kenneth BaillieAnders MälarstigAlexander P ReinerJames F WilsonXia ShenPublished in: Circulation (2022)
Human plasma ACE2 shares a genetic basis with cardiovascular disease, COVID-19, and other related diseases. The genetic architecture of the ACE2 protein is mapped, providing a useful resource for further biological and clinical studies on this coronavirus receptor.