Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation.
Yuya YamashiroTsuyoshi SaitoTakuo HayashiTakashi MurakamiYuka YanaiSho TsuyamaYoshiyuki SueharaKazuya TakamochiTakashi YaoPublished in: Histopathology (2020)
Enteroblastic marker-positive CRC could be grouped together as CAED regardless of clear cell cytoplasm. Using this definition, the frequency of CAED is 4.0% and has a poorer prognosis than that for conventional CRCs. HER2 targeted therapy would be a meaningful treatment for CAED, and CAEDs contain both MSI-H and MSI-stable CRCs, although the MSS phenotype is dominant.