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Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity.

Kathryn M TullySalomon TendlerLukas Michael CarterSai Kiran SharmaZachary V SamuelsKomal MandleywalaJoshua A KorsenAvelyn Mae V Delos ReyesAlessandra PiersigilliWilliam D TravisTriparna SenNaga Vara Kishore PillarsettyJohn T PoirierCharles M RudinJason S Lewis
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Together, the compelling antitumor efficacy, pathologic CRs, and mild and transient toxicity profile demonstrate strong potential for clinical translation of [177Lu]Lu-DTPA-CHX-A"-SC16.
Keyphrases
  • small cell lung cancer
  • oxidative stress
  • neoadjuvant chemotherapy
  • squamous cell carcinoma
  • locally advanced
  • drug delivery
  • lymph node
  • brain injury
  • rectal cancer