Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity.
Kathryn M TullySalomon TendlerLukas Michael CarterSai Kiran SharmaZachary V SamuelsKomal MandleywalaJoshua A KorsenAvelyn Mae V Delos ReyesAlessandra PiersigilliWilliam D TravisTriparna SenNaga Vara Kishore PillarsettyJohn T PoirierCharles M RudinJason S LewisPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Together, the compelling antitumor efficacy, pathologic CRs, and mild and transient toxicity profile demonstrate strong potential for clinical translation of [177Lu]Lu-DTPA-CHX-A"-SC16.