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Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction.

Chenliang ZhangYiChun DuanChen HuangLiping Li
Published in: Cellular & molecular biology letters (2023)
This study shows that inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction. SQSTM1 T269/S272 phosphorylation inhibits the S403 phosphorylation, boosting the aggresome formation of ubiquitinated protein and shielding cells from proteotoxic crisis.
Keyphrases
  • protein kinase
  • oxidative stress
  • public health
  • protein protein
  • amino acid