Atorvastatin's Therapeutic Potential in Atherosclerosis: Inhibiting TGF-β-Induced Proteoglycan Glycosaminoglycan Chain Elongation through ROS-ERK1/2-Smad2L Signaling Pathway Modulation in Vascular Smooth Muscle Cells.
Hossein Ghaderi-ZefrehiGhorban MohammadzadehMojtaba RashidiMaryam AdelipourHossein Babaahmadi RezaeiPublished in: Cell journal (2024)
These data suggest that atorvastatin demonstrates anti-atherogenic properties through the modulation of the ROS-ERK1/2-Smad2L signaling pathway. This provides valuable insight into the potential mechanisms by which atorvastatin exerts its pleiotropic effects against atherosclerosis.
Keyphrases
- signaling pathway
- epithelial mesenchymal transition
- transforming growth factor
- vascular smooth muscle cells
- pi k akt
- induced apoptosis
- dna damage
- cell death
- cardiovascular disease
- angiotensin ii
- reactive oxygen species
- high glucose
- electronic health record
- diabetic rats
- big data
- type diabetes
- machine learning
- endothelial cells
- artificial intelligence