Parainfectious Brown-Séquard syndrome associated with COVID-19.
Lily Ye ChenRachel Diem-Trang TruongSampathkumar ShanmughamPublished in: BMJ case reports (2023)
Acute myelitis encompasses syndromes associated with inflammation of the spinal cord. In cases of inflammatory lesions that only involve a unilateral portion of the axial plane of the cord, Brown-Séquard syndrome may occur, resulting in potential ipsilateral corticospinal, dorsal spinocerebellar, or dorsal column dysfunction or contralateral spinothalamic dysfunction below the level of the lesion. We report a case of an adult male who presented with Brown-Séquard syndrome and with a positive SARS-CoV-2 nasopharyngeal swab PCR test. Neurological symptoms rapidly resolved after initiation of high-dose methylprednisolone. The findings reported not only contribute to documenting a new presentation of neurological complications associated with SARS-CoV-2 infection but also non-exclusively supports the body of literature suggesting the immune-mediated response to this infection as a mechanism of neuropathogenesis. In this case, COVID-19-related acute myelitis responded to treatment with a short regimen of high-dose glucocorticoids.
Keyphrases
- high dose
- sars cov
- spinal cord
- oxidative stress
- coronavirus disease
- respiratory syndrome coronavirus
- neuropathic pain
- case report
- liver failure
- low dose
- stem cell transplantation
- systematic review
- respiratory failure
- drug induced
- spinal cord injury
- aortic dissection
- risk factors
- mass spectrometry
- risk assessment
- depressive symptoms
- combination therapy
- smoking cessation