Two-photon fluorescence and MR bio-imaging of endogenous H2O2 in the tumor microenvironment using a dual-mode nanoprobe.

Hongmei ZhongShengrong YuBingqian LiKangdi HeDian LiXiao WangYong-Xiang Wu

Published in: Chemical communications (Cambridge, England) (2021)

The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based on two-photon carbon quantum dots and MnO2, has been developed for the two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment, and it achieved high selectivity, a great signal-to-noise ratio, a limit of detection (LOD) of 1.425 pM for H2O2, and a two-photon tissue penetration depth of 280 μm.

Keyphrases

living cells
single molecule
fluorescent probe
high resolution
quantum dots
air pollution
energy transfer
monte carlo
particulate matter
magnetic resonance
optical coherence tomography
computed tomography
heavy metals
photodynamic therapy
polycyclic aromatic hydrocarbons