STAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment.
Kelvin AndersonNathan RyanDivya NedungadiFelipe LamenzaMichael SwinglerArham SiddiquiAbhay SatoskarPuja UpadhayaMaciej PietrzakSteve OghumuPublished in: British journal of cancer (2022)
Our findings indicate that STAT1 activity plays an important role in tumorigenicity and immunosuppression during HNSCC development.
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