Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects.

Cara E MoravecHakeem YousefBrian A KinneyRyan Salerno-EichenholzCamillia M MonestimeBenjamin L MartinHoward I Sirotkin

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)

Surprisingly, Sin3b is not essential in zebrafish. sin3b mutants show a decrease in fitness, small size, changes to locomotor behavior, and delayed bone development. We did not detect a role for Sin3b in cell proliferation. Our analysis of the sin3b mutant revealed a more nuanced requirement for zebrafish Sin3b than would be predicted from analysis of mutants in other species. Developmental Dynamics 246:946-955, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

cell proliferation
spinal cord injury
wild type
bone mineral density
single cell
pi k akt