Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS).
Jurandy do Nascimento SilvaNayana Bruna Nery MonçãoRuth Raquel Soares de FariasAntonia Maria das Graças Lopes CitóMariana Helena ChavesMônica Regina Silva de AraújoDaisy Jereissati Barbosa LimaClaudia PessoaAlessandro de LimaEdigênia Cavalcante da Cruz AraújoGardenia Carmen Gadelha MilitãoMarcília Pinheiro da CostaRaffaele CapassoPaulo Michel Pinheiro FerreiraPublished in: Journal of toxicology and environmental health. Part A (2020)
ABTS: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); AcOH: ethyl acetate; ANOVA: analysis of variance; SUS: Brazilian Unified Health System; DC-Mca: dichloromethane fraction from Mimosa caesalpiniifolia stem bark; DMSO: dimethylsulfoxide; DPPH: 1,1-diphenyl-2-picrylhydrazyl; EC50: effective concentration 50%; EtOAc: ethyl acetate; FDA: Food and Drug Administration; GC-Qms: gas chromatograph quadrupole mass spectrometer; GI: genotoxic index; HCT-116: colon carcinoma line; HL-60: promyelocytic leukemia line; HPLC: high-performance liquid chromatography; HRAPCIMS: high resolution atmospheric pressure chemical ionization mass spectrum; IC50: inhibitory concentration 50%; LC50: lethal concentration 50%; MeOH = methyl alcohol; MI: mitotic index; MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide; MutI: mutagenic index; OVCAR-8 = ovarian carcinoma line; PBMC: peripheral blood mononuclear cells; RPMI-1640: Roswell Park Memorial Institute medium; SF-295: glioblastoma line; TEAC: trolox equivalent antioxidant capacity; TLC: thin-layer chromatography; Trolox: 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid.
Keyphrases
- high performance liquid chromatography
- tandem mass spectrometry
- mass spectrometry
- simultaneous determination
- gas chromatography
- high resolution
- liquid chromatography
- solid phase extraction
- ionic liquid
- drug administration
- high resolution mass spectrometry
- bone marrow
- acute myeloid leukemia
- ms ms
- dendritic cells
- high speed
- risk assessment
- carbon dioxide
- alcohol consumption