Model-informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation.

Min Dong Chie EmotoTsuyoshi FukudaDanielle E ArnoldParinda A MehtaRebecca A MarshAlexander A Vinks

Published in: British journal of clinical pharmacology (2021)

An allometry- or body surface area-based starting dosing regimen in combination with individualized Bayesian PK estimation using concentration feedback is proposed for alemtuzumab precision dosing in children undergoing allogeneic HCT.

Keyphrases

young adults
stem cell transplantation
patients undergoing
bone marrow
cell therapy
hematopoietic stem cell
single cell
intensive care unit
emergency department
high dose
stem cells
childhood cancer
low dose
mesenchymal stem cells
cell cycle arrest