Association of baseline neutrophil-to-eosinophil ratio with response to nivolumab plus ipilimumab in patients with metastatic renal cell carcinoma.
Matthew D TuckerLandon C BrownYu-Wei ChenChester KaoNathan HirshmanEmily N KinseyKristin K AncellKathryn E BeckermannNancy B DavisRenee McAlisterKerry SchafferAndrew J ArmstrongMichael R HarrisonDaniel J GeorgeW Kimryn RathmellBrian I RiniTian ZhangPublished in: Biomarker research (2021)
A lower baseline NER was associated with improved clinical outcomes (PFS, OS, and ORR) in patients with mRCC treated with nivolumab plus ipilimumab, and prospective validation of the baseline NER as a predictive biomarker for response to immunotherapy-based combinations in mRCC is warranted.