Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex.

Cristina de la TorreAnita ToscaniCristina Marín-HernándezJonathan A RobsonMaría Carmen TerencioAndrew J P WhiteMaría José AlcarazJames D E T Wilton-Ely Ramón Martínez-MáñezFélix Sancenón

Published in: Journal of the American Chemical Society (2017)

A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.

Keyphrases

living cells
fluorescent probe
induced apoptosis
oxidative stress
quantum dots
cell cycle arrest
reduced graphene oxide
single molecule
type diabetes
high fat diet induced
signaling pathway
adipose tissue
cell proliferation
cell death
wild type