Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function.
Yana Roka-MoiiaKaitlyn AmmannSamuel Miller-GutierrezJawaad SheriffDanny BluesteinJoseph E ItalianoRobert C FlaumenhaftMarvin J SlepianPublished in: bioRxiv : the preprint server for biology (2023)
Shear-generated PDMPs demonstrate phenotypic heterogeneity as to morphologic features and defined patterns of surface receptor alteration, and impose a bidirectional effect on platelet hemostatic function. PDMP heterogeneity suggests that a range of mechanisms are operative in the microvesiculation process, contributing to CTD coagulopathy and posing opportunities for therapeutic manipulation.
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