Effect of High Altitude Environment on Pharmacokinetic and Pharmacodynamic of Warfarin in Rats.
Xiaojing ZhangHongfang MuYan ZhongRong WangWenbin Li
Published in: Current drug metabolism (2024)
High altitude environment inhibited the metabolism and increased the absorption of warfarin in rats and increased the effect of anticoagulant effect, suggesting that the optimal dose of warfarin for patients at high altitude should be reassessed.