Infusion of haploidentical NKG2D-CAR-T CD45RA- cells in two pediatric patients with advanced relapsed and refractory acute leukemia was safe but achieved no clinical benefits.
Adrián FernándezPérez-Martínez AntonioAdela EscuderoIsabel MironesBerta GonzálezRaquel de PazNerea MatamalaLaura ClaresAlfonso NavarroGalán-Gómez VíctorIsabel Martínez-RomeraJoaquin Martinez LopezAlejandra LeivasMar Valés-GómezCristina FerrerasLucía FernándezPublished in: Leukemia & lymphoma (2022)
Keyphrases
- induced apoptosis
- nk cells
- acute lymphoblastic leukemia
- cell cycle arrest
- acute myeloid leukemia
- stem cell transplantation
- rheumatoid arthritis
- bone marrow
- diffuse large b cell lymphoma
- low dose
- multiple myeloma
- hodgkin lymphoma
- endoplasmic reticulum stress
- ankylosing spondylitis
- oxidative stress
- disease activity
- natural killer cells
- young adults
- high dose
- interstitial lung disease