A positive-negative mode of population covariation links brain connectivity, demographics and behavior.
Stephen M SmithThomas E NicholsDiego VidaurreAnderson M WinklerTimothy E J BehrensMatthew F GlasserKamil UgurbilDeanna M BarchDavid C Van EssenKarla L MillerPublished in: Nature neuroscience (2015)
We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
Keyphrases
- resting state
- functional connectivity
- white matter
- high resolution
- endothelial cells
- multiple sclerosis
- cardiovascular disease
- physical activity
- quality improvement
- type diabetes
- data analysis
- machine learning
- big data
- blood brain barrier
- mass spectrometry
- atomic force microscopy
- photodynamic therapy
- brain injury
- fluorescence imaging
- single molecule
- artificial intelligence