IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study.
Yunlei LiJessica G C A M Buijs-GladdinesKirsten Canté-BarrettAndrew P StubbsEric M VroegindeweijWillem K SmitsRonald van MarionWinand N M DinjensMartin HorstmannRoland P KuiperRogier C BuijsmanGuido J R ZamanPeter J van der SpekRob PietersJules P P MeijerinkPublished in: PLoS medicine (2016)
Using an unbiased sequencing approach, we found that specific mutations in IL7R signaling molecules underlie steroid resistance in T-ALL. Future prospective clinical studies should test the ability of inhibitors of MEK, AKT, mTOR, or PI3K/mTOR to restore or enhance steroid sensitivity and improve clinical outcome.