Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis.
Yulan MoLeanne L LeungCelia S L MakXueyu WangWai-Sun ChanLynn M N HuiHermit W M TangMichelle K Y SiuRakesh SharmaDakang XuStephen K W TsuiHextan Y S NganMingo M H YungKaren K L ChanDavid W ChanPublished in: Molecular cancer (2023)
This study uncovers miR-141 as an OvCa-derived exosomal microRNA mediating the tumor-stroma interactions and the formation of tumor-promoting stromal niche through activating YAP1/GROα/CXCRs signaling cascade, providing new insight into therapy for OvCa patients with peritoneal metastases.