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Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri .

Ivan KigandaLianne H E WieskeVaderament-Alexe Nchiozem-NgnitedemDuncan ChaloDaniel UmerewenezaAlbert NdakalaWouter A HerreboutRuisheng XiongTomasz M KarpińskiAbiy YenesewMáté Erdélyi
Published in: Journal of natural products (2024)
Three new dihydroflavonols, gloverinols A-C ( 1 - 3 ), a new flavon-3-ol, gloverinol D ( 4 ), two new isoflavans, gloveriflavan A ( 5 ) and B ( 6 ), and seven known compounds were isolated from the root bark of Dalbergia gloveri . The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B ( 2 ), gloveriflavan B ( 6 ), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone ( 10 ) were the most active against Staphylococcus aureus , with MIC values of 9.2, 18.4, and 14.2 μM, respectively.
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