Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20-90 Years.

Barbara Pospieszna Krzysztof Kusy Ewa Maria Slominska Monika Ciekot-Sołtysiak Jacek Zielinski

Published in: Clinical interventions in aging (2023)

Such a profile of change suggests a deterioration of the GTP-related regulatory function in older individuals. Our study explicitly shows that lifelong sports participation, especially of sprint-oriented nature, allows for maintaining a higher erythrocyte guanylate pool concentration, supporting cells' energy metabolism, regulatory and transcription properties, and thus more efficient overall body functioning.

Keyphrases

physical activity
transcription factor
induced apoptosis
high intensity
cell cycle arrest
high school
middle aged
community dwelling
oxidative stress
endoplasmic reticulum stress
resistance training
signaling pathway
cell proliferation
drug induced