Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia.
Yu CuiNan-Nan ZhangDan WangWei-Hong MengHui-Sheng ChenPublished in: Journal of inflammation research (2022)
This is the first report that MCP exerts neuroprotective effects in ischemic stroke through blocking galectin-3, which may be mediated by inhibiting the activation of NLRP3 inflammasome via TLR4/NF-κB signaling pathway in microglia.
Keyphrases
- signaling pathway
- nlrp inflammasome
- inflammatory response
- pi k akt
- ischemia reperfusion injury
- toll like receptor
- induced apoptosis
- lps induced
- epithelial mesenchymal transition
- immune response
- neuropathic pain
- atrial fibrillation
- nuclear factor
- subarachnoid hemorrhage
- spinal cord injury
- spinal cord
- cerebral ischemia