Detection of cancer-associated cachexia in lung cancer patients using whole-body [ 18 F]FDG-PET/CT imaging: A multi-centre study.

Daria FerraraElisabetta M AbenavoliThomas BeyerStefan GruenertMarcus HackerSwen HesseLukas HofmannSmilla PusitzMichael RullmannOsama SabriRoberto SciagràLalith Kumar Shiyam SundarAnke TönjesHubert WirtzJosef YuArmin Frille

Published in: Journal of cachexia, sarcopenia and muscle (2024)

F]FDG-PET/CT imaging reveals groupwise differences in the multi-organ metabolism of LCP with and without CAC, thus highlighting systemic metabolic aberrations symptomatic of cachectic patients. Based on a retrospective cohort, our ML model identified patients with CAC with good accuracy. However, its performance in patients developing CAC was suboptimal. A prospective, multi-centre study has been initiated to address the limitations of the present retrospective analysis.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
high resolution
mass spectrometry
dna methylation