Strontium-Containing Barium Titanate-Modified Titanium for Enhancement of Osteointegration.
Jielong ZhouLinjia JianJuning XieShi ChengBaoe LiDonghui WangHongwei ShaoYu ZhangFeng PengPublished in: ACS biomaterials science & engineering (2022)
One of the major challenges for Ti-based implants is insufficient osteointegration, which might result in the loosening of the implant. In this study, we fabricated strontium (Sr)-containing barium titanate (BST) on the surface of Ti to improve the bioactivity for osteointegration enhancement. The introduction of Sr significantly reduced the crystallization time and improved crystallinity, which was proved by X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. Compared with Ti, the BST film showed greater wettability surface and lower elastic modulus and hardness. Furthermore, in synergy with the release of Sr ions, the BST film improved early adhesion and followed osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, the bone implantation experiment suggested that the BST film could significantly improve the in vivo osteogenesis and osteointegration capabilities of Ti implants. In summary, this study revealed that BST-modified Ti has potential application in bone repair.
Keyphrases
- electron microscopy
- soft tissue
- mesenchymal stem cells
- high resolution
- bone regeneration
- room temperature
- reduced graphene oxide
- stem cells
- magnetic resonance imaging
- oxidative stress
- risk assessment
- bone marrow
- computed tomography
- cystic fibrosis
- bone loss
- escherichia coli
- single molecule
- pseudomonas aeruginosa
- dual energy
- biofilm formation
- solid state
- crystal structure