Sexually Dimorphic Pattern of Pain Mitigation Following Prophylactic Regenerative Peripheral Nerve Interface (RPNI) in a Rat Neuroma Model.

Amir DehdashtianJagienka H TimekShelby R SvientekMary Jane RischJared V BratleyAnna E RieggerTheodore A KungPaul S CedernaStephen William Peter Kemp

Published in: Neurosurgery (2023)

Prophylactic RPNI can prevent neuroma site pain in both sexes. However, attenuation of both cold allodynia and thermal allodynia occurred in males exclusively, potentially because of their sexually dimorphic effect on pathological changes of the central nervous system.

Keyphrases

neuropathic pain
peripheral nerve
chronic pain
spinal cord
pain management
spinal cord injury
stem cells
mesenchymal stem cells
oxidative stress
climate change
cell therapy
cerebrospinal fluid