Sputum cell-free DNA for detection of alterations of multiple driver genes in lung adenocarcinoma.
Zheng WangLin LiYifei WangXiaoguang LiYan XuMengzhao WangLi LiangXiaonan WuMin TangYuanming LiShurong HeJun DuLei HeMingjun SunLi YangJing DiFei GaiDongge LiuPublished in: Cancer cytopathology (2022)
This study demonstrated that sputum cfDNA were successfully used for the detection of multiple driver genes by NGS. Sputum cfDNA could be a valuable surrogate clinical sample for all-in-one test of mutations to guide target therapies, especially for patients with advanced LAC and malignant sputum.