5-year follow-up results of a JCOG1104 (OPAS-1) phase III non-inferiority trial to compare 4 courses and 8 courses of S-1 adjuvant chemotherapy for pathological stage II gastric cancer.
Takaki YoshikawaMasanori TerashimaJunki MizusawaSouya NunobeYasunori NishidaTakanobu YamadaMasahide KajiTakashi NomuraShinji HatoYasuhiro ChodaHiroshi YabusakiKazuhiro YoshidaKazunari MisawaToru MasuzawaMasahiro TsudaYasuyuki KawachiHiroshi KatayamaHaruhiko FukudaYukinori KurokawaNarikazu BokuTakeshi SanoMitsuru SasakoPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)
The survival of the four-course arm was slightly but consistently inferior to that of the eight-course arm. Eight-course S-1 should thus remain the standard adjuvant chemotherapy for pathological stage II gastric cancer.