Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.

Matthew R TrendowskiOmar El-CharifMark J RatainPatrick MonahanZepeng Mu Heather E WheelerPaul C DinhDarren R FeldmanShirin Ardeshir-Rouhani-FardRobert J HamiltonDavid J VaughnChunkit FungChristian KollmannsbergerTaisei MushirodaMichiaki KuboRobyn HanniganFrederick StrathmannLawrence H EinhornSophie D FossaLois B TravisM Eileen Dolan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

This study indicates that residual platinum values are correlated with several cisplatin-related toxicities. One genetic variant is associated with these levels.

Keyphrases

genome wide analysis
genome wide
gene expression
squamous cell carcinoma
copy number
radiation therapy
dna methylation