Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1/Smads Pathway in Rats.

Yijia XiangChanghong CaiYonghui WuLebing YangShiyong YeHuan ZhaoChun-Lai Zeng

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

Compared to the control group, RVSP and RI were increased in the MCT group (ρ < 0.05). Additionally, TGF-β1, Smad2/3, P-Smad2/3, and MMP2 expressions were obviously increased (ρ < 0.01). Compared to the MCT group, RVSP and RI were decreased in the MCT + ICA group (ρ < 0.05). TGF-β1, Smad2/3, P-Smad2/3, and MMP2 expressions were also inhibited in the icariin treatment groups (ρ < 0.05). Conclusions. Icariin may suppress MCT-induced PAH via the inhibition of the TGFβ1-Smad2/3 pathway.

Keyphrases

transforming growth factor
pulmonary arterial hypertension
epithelial mesenchymal transition
pulmonary hypertension
pulmonary artery
high glucose
diabetic rats
signaling pathway
drug induced
oxidative stress
cell migration