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Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis.

Fanchen WangJiacong XiaoMiao LiQi HeXintian WangZhaofeng PanShaocong LiHaibin WangChi Zhou
Published in: PloS one (2024)
Our research suggests that Picroside II can inhibit chondrocyte pyroptosis and ameliorate osteoarthritis progression by modulating the MAPK/NF-κB signaling pathway.
Keyphrases
  • signaling pathway
  • pi k akt
  • nlrp inflammasome
  • induced apoptosis
  • rheumatoid arthritis
  • epithelial mesenchymal transition
  • knee osteoarthritis
  • oxidative stress
  • immune response
  • cell proliferation
  • lps induced