Huoxue Wentong Formula ameliorates myocardial infarction in rats through inhibiting CaMKII oxidation and phosphorylation.
Tiantian LiuQingqing WangKui-Wu YaoPublished in: Chinese medicine (2020)
Our study demonstrates that HXWTF improves myocardial infarction possibly through inhibiting CaMKII oxidation and phosphorylation levels, facilitating angiogenic function and alleviating cardiomyocyte apoptosis. Thus, therapeutics targeting CaMKII activities may be a promising strategy for rescuing ischemic cardiomyopathy.
Keyphrases
- heart failure
- signaling pathway
- left ventricular
- hydrogen peroxide
- oxidative stress
- protein kinase
- endoplasmic reticulum stress
- small molecule
- mouse model
- cancer therapy
- cell cycle arrest
- angiotensin ii
- human milk
- ischemia reperfusion injury
- cell proliferation
- blood brain barrier
- cerebral ischemia
- subarachnoid hemorrhage
- preterm infants