Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs.

Carla Rohrer Bley Friederike WolfPatrik Gonçalves JorgeVeljko GriljIoannis PetridisBenoit PetitTill Tobias Böhlen Raphaël MoeckliCharles LimoliJean Bourhis Valeria S Meier Marie-Catherine Vozenin

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

The reported outcomes point to the caveats of translating single-high-dose FLASH-radiotherapy and emphasizes the need for caution and further investigations. See related commentary by Maity and Koumenis, p. 3636.

Keyphrases

locally advanced
squamous cell carcinoma
high dose
early stage
radiation therapy
radiation induced
rectal cancer
low dose
stem cell transplantation
oxidative stress
type diabetes