Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease.

Alireza FaridarMatthew VasquezAaron D ThomeZheng YinHui XuanJing Hong WangShixiang WenXuping LiJason R ThonhoffWeihua ZhaoHong ZhaoDavid R BeersStephen T C WongJoseph C MasdeuStanley H Appel

Published in: Acta neuropathologica communications (2022)

Ex vivo expanded Tregs with amplified immunomodulatory function, suppressed neuroinflammation and alleviated AD pathology in vivo. Our results provide preclinical evidences for Treg cell therapy as a potential treatment strategy in AD.

Keyphrases

cell therapy
regulatory t cells
stem cells
mesenchymal stem cells
lipopolysaccharide induced
traumatic brain injury
endothelial cells
dendritic cells
lps induced
cognitive impairment
cerebral ischemia
induced pluripotent stem cells
combination therapy
bone marrow
brain injury
subarachnoid hemorrhage