Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells.

Wenting PanZhouwei ZhangHannah KimballFangfang QuKyler BerlindKonrad H StopsackGwo-Shu Mary LeeToni K ChoueiriPhilip W Kantoff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our studies suggest that AA treatment upregulates pCREB1, which enhances CBP/p300 activity, leading to global gene expression alterations, subsequently resulting in drug resistance development. Combining AA with therapies targeting resistance mechanisms may provide a more effective treatment strategy.

Keyphrases

gene expression
dna methylation
combination therapy
protein kinase
smoking cessation