Role of proteinase-activated receptors 1 and 2 in nonsteroidal anti-inflammatory drug enteropathy.

Matteo FornaiRocchina ColucciCarolina PellegriniLaura BenvenutiGianfranco NataleLarisa RyskalinCorrado BlandizziLuca Antonioli

Published in: Pharmacological reports : PR (2020)

PAR2 is involved in the pathogenesis of indomethacin enteropathy, through pro-inflammatory mechanisms and an impairment of the intestinal epithelial barrier. PAR1 activation and PAR2 inhibition could represent suitable strategies for the prevention of NSAID enteropathy.

Keyphrases

anti inflammatory
emergency department
drug induced
adverse drug