FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1.

Joy EbonwuRia LassaunièreMaria PaximadisRenate StrehlauGlenda E GrayLouise Kuhn Caroline T Tiemessen

Published in: PloS one (2022)

Collectively, our findings suggest that the FcγRIIb-232TT genotype exerts a controlling influence on infant susceptibility to HIV-1 infection. We also show a role for less studied variants-FCGR3A duplication and homozygous HNA1a. These findings provide additional insight into a role for FcγRs in HIV-1 infection in children.

Keyphrases

antiretroviral therapy
hiv infected
copy number
human immunodeficiency virus
hiv positive
hepatitis c virus
genome wide
hiv testing
gene expression
men who have sex with men