Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer.
Jonas SteenbruggeKoen BreyneKristel DemeyereOlivier De WeverNiek N SandersWim Van Den BroeckCecile ColpaertPeter VermeulenSteven Van LaereEvelyne MeyerPublished in: Journal of experimental & clinical cancer research : CR (2018)
The current experimental study with an innovative immunocompetent intraductal model for TNBC pinpoints towards a metastasis-supporting M1 to M2 macrophage polarization in the mammary ducts mediated by 4T1-derived signaling. We propose to explore this process as immunotherapeutic target.
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