Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study.

Alessandro MarconFrancesca LocatelliDirk KeidelAnna B Beckmeyer-BorowkoIsa CerveriShyamali C DharmageElaine FuertesJudith M Garcia-AymerichJoachim HeinrichMedea ImbodenChrister JanssonAne JohannessenBénédicte LeynaertSilvia Pascual ErquiciaGiancarlo PesceEmmanuel SchaffnerCecilie SvanesIsabel UrrutiaDeborah L JarvisNicole M Probst-HenschSimone Accordininull null

Published in: Thorax (2018)

Our study suggests that increased airway responsiveness is an independent risk factor for COPD. Further research should clarify whether early treatment in patients with high responsiveness can slow down disease progression.

Keyphrases

chronic obstructive pulmonary disease
lung function
risk factors
cystic fibrosis
combination therapy
replacement therapy