Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis.
Joseph M CollacoScott M BlackmanKaren S RaraighHarriet CorvolJohanna M RommensRhonda G PacePierre-Yves BoelleJohn McGreadyPatrick R SosnayLisa J StrugMichael R KnowlesGarry R CuttingPublished in: American journal of respiratory and critical care medicine (2017)
Variation in the CFTR gene is the predominant cause of sweat chloride variation; most of the non-CFTR variation is caused by testing variability and unique environmental factors. If test precision and accuracy can be improved, sweat chloride measurement could be a valuable biomarker for assessing response to therapies directed at mutant CFTR.