Molecular heterogeneity of pediatric choroid plexus carcinomas determines the distinctions in clinical course and prognosis.

Margarita Zaytseva Andge Valiakhmetova Ludmila YaskoAlexey SamarinLudmila PapushaAnastasia ShekhtmanNatalia UsmanKirill VoroninAlexander Karachunsky Galina A Novichkova Alexander E Druy

Published in: Neuro-oncology (2022)

CPCs split into at least two molecular subtypes distinguished both genomically and transcriptomically. Clusterization of the tumors into Ped_CPC1 and Ped_CPC2 significantly correlates with survival. The distinction may prove relevant in clinical trials for dedicated and patient-oriented optimization of clinical protocols for these rare tumors.

Keyphrases

clinical trial
case report
high grade
single cell
ultrasound guided
open label
free survival
study protocol